Skip to Main Content Doctors Locations Medical Services Patients & Visitors About Find Care My Sanford Chart Sanford USD Medical Center Hospital Sioux Falls SD Sanford USD Medical Center Home Find Locations Sanford USD Medical Center Print Sanford USD Medical Center The Sanford USD Medical Center in Sioux Falls provides leading care for patients from across the Midwest. As the largest hospital in South Dakota and a teaching hospital for the University of South Dakota Sanford School of Medicine, we are proud to offer the latest in innovative care. Our highly skilled medical teams are known for their passion, leadership and dedication to patients. We have been consistently named a Top 100 Hospital in the nation. Our comprehensive care includes emergency air transport, neonatal and pediatric intensive care, transplant services and specialty centers in children’s care, heart, cancer, neuroscience, sports medicine and women’s health. With 545 beds and 4,000 employees, we are here to meet you and your family’s health care needs. The Sanford USD Medical Center is the only Level I Adult and Level II Pediatric Trauma Center in South Dakota verified by the American College of Surgeons. When every second counts, we’re here to provide the highest level of care to our patients. Sanford USD Medical Center participates in the Increasing Organ Transplant Access (IOTA) model. Learn more about this program. View Parking Map Specialties Anesthesiology Emergency Medicine Gastroenterology Hospice Integrative Health Midwifery Neurocritical Care Orthopedic Surgery Orthopedic Trauma Surgery Palliative Care Physical Therapy Types of Care Cardiac Catheterization Laboratory Low Intervention Birth Pediatric Trauma Robotic Surgery Senior Services Total Joint Replacement Wound Care (605) 333-1000 Map Satellite Map data ©2026 Terms 1305 W. 18th St. Sioux Falls, South Dakota 57105 Get Directions Primary Hours Open 24/7 Sanford USD Medical Center Doctors Filter By Type of Care